{"id":193,"date":"2015-01-15T16:23:10","date_gmt":"2015-01-15T16:23:10","guid":{"rendered":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/?p=193"},"modified":"2025-06-13T16:24:47","modified_gmt":"2025-06-13T16:24:47","slug":"metabotropic-glutamate-receptor-3-activation-is-required-for-long-term-depression-in-medial-prefrontal-cortex-and-fear-extinction","status":"publish","type":"post","link":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/2015\/01\/15\/metabotropic-glutamate-receptor-3-activation-is-required-for-long-term-depression-in-medial-prefrontal-cortex-and-fear-extinction\/","title":{"rendered":"Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction"},"content":{"rendered":"

Abstract<\/h2>\r\n

Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3<\/sub>) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3<\/sub>\u00a0influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3<\/sub>\u00a0can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3<\/sub>\u00a0negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3<\/sub>\u00a0as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3<\/sub>\u00a0may be useful in alleviating prefrontal impairments associated with several CNS disorders.<\/p>\r\n\r\n

Funding Source<\/h2>\r\n
\r\n\r\nThis work was supported by a grant from the National Institute of Neurological Disease and Stroke (NS031373) (to P.J.C.), a postdoctoral fellowship from the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation (to A.G.W.), and a National Institutes of Health predoctoral Training Grant (T32 GM007628) (to C.J.W.).\r\n

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    Kiritoshi, T., & Neugebauer, V. (2015). Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex.\u00a0Neuropharmacology<\/i>,\u00a095<\/i>, 388\u2013394.\u00a0https:\/\/doi.org\/10.1016\/j.neuropharm.2015.04.003<\/a><\/div><\/li>\r\n \t
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    Ellaithy, A., Younkin, J., Gonz\u00e1lez-Maeso, J., & Logothetis, D. E. (2015). Positive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatment.\u00a0Trends in neurosciences<\/i>,\u00a038<\/i>(8), 506\u2013516.\u00a0https:\/\/doi.org\/10.1016\/j.tins.2015.06.002<\/a><\/div><\/li>\r\n<\/ol>\r\n<\/div>","protected":false},"excerpt":{"rendered":"Abstract Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, …","protected":false},"author":7,"featured_media":194,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-193","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-feature-publications"],"acf":[],"_links":{"self":[{"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/posts\/193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/comments?post=193"}],"version-history":[{"count":1,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/posts\/193\/revisions"}],"predecessor-version":[{"id":195,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/posts\/193\/revisions\/195"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/media\/194"}],"wp:attachment":[{"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/media?parent=193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/categories?post=193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wwwtest.pharmacy.wisc.edu\/faculty\/wenthur-lab\/wp-json\/wp\/v2\/tags?post=193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}