Kwon Research Group

Publications

Featured Publications

Production of paclitaxel-loaded PEG-b-PLA micelles using PEG for drug loading and freeze-drying

Acyl and Oligo(Lactic Acid) Prodrugs for PEG-b-PLA and PEG-b-PCL Nano-Assemblies for Injection

Multimodal imaging demonstrates enhanced tumor exposure of PEGylated FUD peptide in breast cancer

Probing the Subcutaneous Absorption of a PEGylated FUD Peptide Nanomedicine via In Vivo Fluorescence Imaging

Oligolactic Acid Prodrug-Based Nanomedicines for Cancer Therapy

Poly(ethylene glycol)-block-poly(d,l-lactic acid) Micelles Containing Oligo(lactic acid) 8-paclitaxel Prodrug: In Vivo Conversion and Antitumor Efficacy

All Publications

  1. Lee, H. J., Bernau, K., Harr, T. J., Rosenkrans, Z. T., Kessler, G. A., Stott, K., Oler, A. T., Rahar, B., Zhu, T., Medina-Guevara, Y., Gupta, N., Cho, I., Gari, M. K., Burkel, B. M., Jeffery, J. J., Weichmann, A. M., Tomasini-Johansson, B. R., Ponik, S. M., Engle, J. W., Hernandez, R., … Sandbo, N. (2024). [64Cu]Cu-PEG-FUD peptide for noninvasive and sensitive detection of murine pulmonary fibrosis. Science advances, 10(15), eadj1444. https://doi.org/10.1126/sciadv.adj1444
  2. Rasoulianboroujeni, M., de Villiers, M. M., & Kwon, G. S. (2023). Entropy-Driven Liquid-Liquid Phase Separation Transition to Polymeric Micelles. The journal of physical chemistry. B, 127(37), 7925–7936. https://doi.org/10.1021/acs.jpcb.3c03854
  3. Lee, H. J., Tomasini-Johansson, B. R., Gupta, N., & Kwon, G. S. (2023). Fibronectin-targeted FUD and PEGylated FUD peptides for fibrotic diseases. Journal of controlled release : official journal of the Controlled Release Society, 360, 69–81. https://doi.org/10.1016/j.jconrel.2023.06.008
  4. Repp, L., Skoczen, S. L., Rasoulianboroujeni, M., Stern, S. T., & Kwon, G. S. (2023). Plasma Stability and Plasma Metabolite Concentration-Time Profiles of Oligo(Lactic Acid)8-Paclitaxel Prodrug Loaded Polymeric Micelles. The AAPS journal, 25(3), 39. https://doi.org/10.1208/s12248-023-00807-4
  5. Eom, J. Y., Choi, S. H., Kim, H. J., Kim, D. H., Bae, J. H., Kwon, G. S., Lee, D. H., Hwang, J. H., Kim, D. K., Baek, M. C., & Cho, Y. E. (2022). Hemp-Derived Nanovesicles Protect Leaky Gut and Liver Injury in Dextran Sodium Sulfate-Induced Colitis. International journal of molecular sciences, 23(17), 9955. https://doi.org/10.3390/ijms23179955
  6. Lee, H. J., Gari, M. K., Inman, D. R., Rosenkrans, Z. T., Burkel, B. M., Olson, A. P., Engle, J. W., Hernandez, R., Ponik, S. M., & Kwon, G. S. (2022). Multimodal imaging demonstrates enhanced tumor exposure of PEGylated FUD peptide in breast Cancer. Journal of controlled release : official journal of the Controlled Release Society, S0168-3659(22)00533-8. Advance online publication. https://doi.org/10.1016/j.jconrel.2022.08.028
  7. Rasoulianboroujeni, M., Repp, L., Lee, H. J., & Kwon, G. S. (2022). Production of paclitaxel-loaded PEG-b-PLA micelles using PEG for drug loading and freeze-drying. Journal of controlled release : official journal of the Controlled Release Society, S0168-3659(22)00537-5. Advance online publication. https://doi.org/10.1016/j.jconrel.2022.08.032
  8. Repp, L., Unterberger, C. J., Ye, Z., Feltenberger, J. B., Swanson, S. M., Marker, P. C., & Kwon, G. S. (2021). Oligo(Lactic Acid)8-Docetaxel Prodrug-Loaded PEG-b-PLA Micelles for Prostate Cancer. Nanomaterials (Basel, Switzerland), 11(10), 2745. https://doi.org/10.3390/nano11102745
  9. Wang, J., Drelich, A. J., Hopkins, C. M., Mecozzi, S., Li, L., Kwon, G., & Hong, S. (2021). Gold nanoparticles in virus detection: Recent advances and potential considerations for SARS-CoV-2 testing development. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, e1754. Advance online publication. https://doi.org/10.1002/wnan.1754
  10. Lee, S. G., Chae, J., Kim, D. S., Lee, J. B., Kwon, G. S., Kwon, T. K., & Nam, J. O. (2021). Enhancement of the Antiobesity and Antioxidant Effect of Purple Sweet Potato Extracts and Enhancement of the Effects by Fermentation. Antioxidants (Basel, Switzerland), 10(6), 888. https://doi.org/10.3390/antiox10060888
  11. Li, Z., Wang, Y., Ding, Y., Repp, L., Kwon, G. S., Hu, Q., Cell-Based Delivery Systems: Emerging Carriers for Immunotherapy. Adv. Funct. Mater. 2021, 31, 2100088. https://doi.org/10.1002/adfm.202100088
  12. Repp, L., Rasoulianboroujeni, M., Lee, H. J., & Kwon, G. S. (2021). Acyl and oligo(lactic acid) prodrugs for PEG-b-PLA and PEG-b-PCL nano-assemblies for injection. Journal of controlled release : official journal of the Controlled Release Society, 330, 1004–1015. https://doi.org/10.1016/j.jconrel.2020.11.008
  13. Zbyszynski, P., Toraason, I., Repp, L., & Kwon, G. S. (2019). Probing the subcutaneous absorption of a PEGylated FUD peptide nanomedicine via in vivo fluorescence imaging. Nano convergence, 6(1), 22. https://doi.org/10.1186/s40580-019-0192-3
  14. Cote, B., Rao, D., Alany, R. G., Kwon, G. S., & Alani, A. (2019). Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors. Advanced drug delivery reviews, 144, 16–34. https://doi.org/10.1016/j.addr.2019.08.009
  15. Tam, Y. T., Shin, D. H., Chen, K. E., & Kwon, G. S. (2019). Poly(ethylene glycol)-block-poly(d,l-lactic acid) micelles containing oligo(lactic acid)8-paclitaxel prodrug: In Vivo conversion and antitumor efficacy. Journal of controlled release : official journal of the Controlled Release Society, 298, 186–193. https://doi.org/10.1016/j.jconrel.2019.02.017
  16. Tam, Y. T., Repp, L., Ma, Z. X., Feltenberger, J. B., & Kwon, G. S. (2019). Oligo(Lactic Acid)8-Rapamycin Prodrug-Loaded Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Micelles for Injection. Pharmaceutical research, 36(5), 70. https://doi.org/10.1007/s11095-019-2600-0
  17. Tomasini-Johansson, B. R., Zbyszynski, P. W., Toraason, I., Peters, D. M., & Kwon, G. S. (2018). PEGylated pUR4/FUD peptide inhibitor of fibronectin fibrillogenesis decreases fibrosis in murine Unilateral Ureteral Obstruction model of kidney disease. PloS one, 13(10), e0205360. https://doi.org/10.1371/journal.pone.0205360
  18. Tam, Y. T., Huang, C., Poellmann, M., & Kwon, G. S. (2018). Stereocomplex Prodrugs of Oligo(lactic acid) n-Gemcitabine in Poly(ethylene glycol)- block-poly(d,l-lactic acid) Micelles for Improved Physical Stability and Enhanced Antitumor Efficacy. ACS nano, 12(7), 7406–7414. https://doi.org/10.1021/acsnano.8b04205
  19. Zbyszynski, P., Tomasini-Johansson, B. R., Peters, D. M., & Kwon, G. S. (2018). Characterization of the PEGylated Functional Upstream Domain Peptide (PEG-FUD): a Potent Fibronectin Assembly Inhibitor with Potential as an Anti-Fibrotic Therapeutic. Pharmaceutical research, 35(7), 126. https://doi.org/10.1007/s11095-018-2412-7
  20. Shin, D. H., & Kwon, G. S. (2017). Pre-clinical evaluation of a themosensitive gel containing epothilone B and mTOR/Hsp90 targeted agents in an ovarian tumor model. Journal of controlled release : official journal of the Controlled Release Society, 268, 176–183. https://doi.org/10.1016/j.jconrel.2017.10.022
  21. Li, H. Y., Chen, Z., Ho, L. W., Chan, P. S., Li, Q., Leung, S. C., Zhang, B., Lai, K. L., Kwon, G. S., Choi, C., & Lee, W. (2017). Oligonucleotide-conjugated nanoparticles for targeted drug delivery via scavenger receptors class A: An in vitro assessment for proof-of-concept. International journal of pharmaceutics, 532(1), 647–655. https://doi.org/10.1016/j.ijpharm.2017.08.074
  22. Alvarez, C., Andes, D. R., Kang, J. Y., Krug, C., & Kwon, G. S. (2017). Antifungal Efficacy of an Intravenous Formulation Containing Monomeric Amphotericin B, 5-Fluorocytosine, and Saline for Sodium Supplementation. Pharmaceutical research, 34(5), 1115–1124. https://doi.org/10.1007/s11095-017-2121-7
  23. Tomoda, K., Chiang, H. C., Kozak, K. R., & Kwon, G. S. (2017). Injectable (-)-gossypol-loaded Pluronic P85 micelles for cancer chemoradiotherapy. International journal of radiation biology, 93(4), 402–406. https://doi.org/10.1080/09553002.2016.1257833
  24. Seo, J. S., Min, B. S., Kim, Y. J., Cho, J. M., Kwon, G. S., Lim, B. P., Chang, S. J., & Kim, D. I. (2017). Characterization of human hybrid cell line, F2N78, through a comparison of culture performances and protein qualities. Biotechnology letters, 39(4), 501–509. https://doi.org/10.1007/s10529-016-2281-2
  25. Le, B., Powers, G. L., Tam, Y. T., Schumacher, N., Malinowski, R. L., Steinke, L., Kwon, G., & Marker, P. C. (2017). Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer. PloS one, 12(3), e0174658. https://doi.org/10.1371/journal.pone.0174658
  26. Shin, D. H., & Kwon, G. S. (2017). Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy. International journal of pharmaceutics, 518(1-2), 307–311. https://doi.org/10.1016/j.ijpharm.2017.01.006
  27. Tomoda, K., Tam, Y. T., Cho, H., Buehler, D., Kozak, K. R., & Kwon, G. S. (2017). Triolimus: A Multi-Drug Loaded Polymeric Micelle Containing Paclitaxel, 17-AAG, and Rapamycin as a Novel Radiosensitizer. Macromolecular bioscience, 17(1), 10.1002/mabi.201600194. https://doi.org/10.1002/mabi.201600194
  28. Cho, H., Gao, J., & Kwon, G. S. (2016). PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels for drug delivery. Journal of controlled release : official journal of the Controlled Release Society, 240, 191–201. https://doi.org/10.1016/j.jconrel.2015.12.015
  29. McKenzie, M., Betts, D., Suh, A., Bui, K., Tang, R., Liang, K., Achilefu, S., Kwon, G. S., & Cho, H. (2016). Proof-of-Concept of Polymeric Sol-Gels in Multi-Drug Delivery and Intraoperative Image-Guided Surgery for Peritoneal Ovarian Cancer. Pharmaceutical research, 33(9), 2298–2306. https://doi.org/10.1007/s11095-016-1968-3
  30. Alvarez, C., Shin, D. H., & Kwon, G. S. (2016). Reformulation of Fungizone by PEG-DSPE Micelles: Deaggregation and Detoxification of Amphotericin B. Pharmaceutical research, 33(9), 2098–2106. https://doi.org/10.1007/s11095-016-1948-7
  31. Tam, Y. T., Gao, J., & Kwon, G. S. (2016). Oligo(lactic acid)n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity. Journal of the American Chemical Society, 138(28), 8674–8677. https://doi.org/10.1021/jacs.6b03995
  32. Kang, J. Y., Gao, J., Shin, D. H., Alvarez, C., Zhong, W., & Kwon, G. S. (2016). Pharmacokinetics and Renal Toxicity of Monomeric Amphotericin B in Rats after a Multiple Dose Regimen. Pharmaceutical nanotechnology, 4(1), 16–23. https://doi.org/10.2174/2211738504666160301233754
  33. Lim, B. R., Choi, H. J., Kwon, G. S., & Joo, W. H. (2015). Enhancement of solvent tolerance in Pseudomonas sp. BCNU 106 with trehalose. Letters in applied microbiology, 61(6), 607–612. https://doi.org/10.1111/lam.12504
  34. Tomoda, K., Chiang, C., Kozak, K. R., & Kwon, G. S. (2015). Examination of Gossypol-Pluronic Micelles as Potential Radiosensitizers. The AAPS journal, 17(6), 1369–1375. https://doi.org/10.1208/s12248-015-9809-6
  35. Jang, K. J., Kwon, G. S., Jeong, J. W., Kim, C. H., Yoon, H. M., Kim, G. Y., Shim, J. H., Moon, S. K., Kim, W. J., & Choi, Y. H. (2015). Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT. Journal of bioscience and bioengineering, 119(3), 351–357. https://doi.org/10.1016/j.jbiosc.2014.08.008
  36. Cho, H., Lai, T. C., Tomoda, K., & Kwon, G. S. (2015). Polymeric micelles for multi-drug delivery in cancer. AAPS PharmSciTech, 16(1), 10–20. https://doi.org/10.1208/s12249-014-0251-3
  37. Wyche, T. P., Dammalapati, A., Cho, H., Harrison, A. D., Kwon, G. S., Chen, H., Bugni, T. S., & Jaskula-Sztul, R. (2014). Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo. Cancer gene therapy, 21(12), 518–525. https://doi.org/10.1038/cgt.2014.57
  38. Cho, H., & Kwon, G. S. (2014). Thermosensitive poly-(d,l-lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly-(d,l-lactide-co-glycolide) hydrogels for multi-drug delivery. Journal of drug targeting, 22(7), 669–677. https://doi.org/10.3109/1061186X.2014.931406
  39. Kwon G. (2014). Kazunori Kataoka editorial. Journal of drug targeting, 22(7), 555. https://doi.org/10.3109/1061186X.2014.922978
  40. Cho, H., Cho, C. S., Indig, G. L., Lavasanifar, A., Vakili, M. R., & Kwon, G. S. (2014). Polymeric micelles for apoptosis-targeted optical imaging of cancer and intraoperative surgical guidance. PloS one, 9(2), e89968. https://doi.org/10.1371/journal.pone.0089968
  41. Kim, C. S., Lee, J. B., Kim, B. S., Nam, Y. H., Shin, K. S., Kim, J. W., Kim, J. E., & Kwon, G. S. (2014). A technique for the prevention of greenhouse whitefly (Trialeurodes vaporariorum) using the entomopathogenic fungus Beauveria bassiana M130. Journal of microbiology and biotechnology, 24(1), 1–7. https://doi.org/10.4014/jmb.1306.06033
  42. Yoshida, T., Lai, T. C., Kwon, G. S., & Sako, K. (2013). pH- and ion-sensitive polymers for drug delivery. Expert opinion on drug delivery, 10(11), 1497–1513. https://doi.org/10.1517/17425247.2013.821978
  43. Chen, F., Hong, H., Zhang, Y., Valdovinos, H. F., Shi, S., Kwon, G. S., Theuer, C. P., Barnhart, T. E., & Cai, W. (2013). In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS nano, 7(10), 9027–9039. https://doi.org/10.1021/nn403617j
  44. Nowotschin, S., Costello, I., Piliszek, A., Kwon, G. S., Mao, C. A., Klein, W. H., Robertson, E. J., & Hadjantonakis, A. K. (2013). The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes & development, 27(9), 997–1002. https://doi.org/10.1101/gad.215152.113
  45. Cho, H., Lai, T. C., & Kwon, G. S. (2013). Poly(ethylene glycol)-block-poly(ε-caprolactone) micelles for combination drug delivery: evaluation of paclitaxel, cyclopamine and gossypol in intraperitoneal xenograft models of ovarian cancer. Journal of controlled release : official journal of the Controlled Release Society, 166(1), 1–9. https://doi.org/10.1016/j.jconrel.2012.12.005
  46. Lee, S. H., Kwon, G. S., Kang, M. S., Yoon, H. M., & Kim, C. H. (2012). Comparative study on the effects of bee venom pharmacopuncture according to the treatment method for knee osteoarthritis. Journal of pharmacopuncture, 15(4), 7–14. https://doi.org/10.3831/KPI.2012.15.011
  47. Lai, T. C., Kataoka, K., & Kwon, G. S. (2012). Bioreducible polyether-based pDNA ternary polyplexes: balancing particle stability and transfection efficiency. Colloids and surfaces. B, Biointerfaces, 99, 27–37. https://doi.org/10.1016/j.colsurfb.2011.09.026
  48. Shin, H. C., Cho, H., Lai, T. C., Kozak, K. R., Kolesar, J. M., & Kwon, G. S. (2012). Pharmacokinetic study of 3-in-1 poly(ethylene glycol)-block-poly(D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and rapamycin. Journal of controlled release : official journal of the Controlled Release Society, 163(1), 93–99. https://doi.org/10.1016/j.jconrel.2012.04.024
  49. Hasenstein, J. R., Shin, H. C., Kasmerchak, K., Buehler, D., Kwon, G. S., & Kozak, K. R. (2012). Antitumor activity of Triolimus: a novel multidrug-loaded micelle containing Paclitaxel, Rapamycin, and 17-AAG. Molecular cancer therapeutics, 11(10), 2233–2242. https://doi.org/10.1158/1535-7163.MCT-11-0987
  50. Diezi, T. A., & Kwon, G. (2012). Amphotericin B/sterol co-loaded PEG-phospholipid micelles: effects of sterols on aggregation state and hemolytic activity of amphotericin B. Pharmaceutical research, 29(7), 1737–1744. https://doi.org/10.1007/s11095-011-0626-z
  51. Chen, T. H., Bae, Y., Furgeson, D. Y., & Kwon, G. S. (2012). Biodegradable hybrid recombinant block copolymers for non-viral gene transfection. International journal of pharmaceutics, 427(1), 105–112. https://doi.org/10.1016/j.ijpharm.2011.09.035
  52. Cho, H., Indig, G. L., Weichert, J., Shin, H. C., & Kwon, G. S. (2012). In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe. Nanomedicine : nanotechnology, biology, and medicine, 8(2), 228–236. https://doi.org/10.1016/j.nano.2011.06.009
  53. Cho, H., & Kwon, G. S. (2011). Polymeric micelles for neoadjuvant cancer therapy and tumor-primed optical imaging. ACS nano, 5(11), 8721–8729. https://doi.org/10.1021/nn202676u
  54. Shin, K. S., Bae, K. S., Lee, K. H., Park, D. S., Kwon, G. S., & Lee, J. B. (2011). Wickerhamomyces ochangensis sp. nov., an ascomycetous yeast isolated from the soil of a potato field. International journal of systematic and evolutionary microbiology, 61(Pt 10), 2543–2546. https://doi.org/10.1099/ijs.0.026682-0
  55. Shin, H. C., Alani, A. W., Cho, H., Bae, Y., Kolesar, J. M., & Kwon, G. S. (2011). A 3-in-1 polymeric micelle nanocontainer for poorly water-soluble drugs. Molecular pharmaceutics, 8(4), 1257–1265. https://doi.org/10.1021/mp2000549
  56. Lai, T. C., Kataoka, K., & Kwon, G. S. (2011). Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency. Biomaterials, 32(20), 4594–4603. https://doi.org/10.1016/j.biomaterials.2011.02.065
  57. Diezi, T. A., Takemoto, J. K., Davies, N. M., & Kwon, G. S. (2011). Pharmacokinetics and nephrotoxicity of amphotericin B-incorporated poly(ethylene glycol)-block-poly(N-hexyl stearate l-aspartamide) micelles. Journal of pharmaceutical sciences, 100(6), 2064–2070. https://doi.org/10.1002/jps.22445
  58. Kenealey, J. D., Subramanian, L., Van Ginkel, P. R., Darjatmoko, S., Lindstrom, M. J., Somoza, V., Ghosh, S. K., Song, Z., Hsung, R. P., Kwon, G. S., Eliceiri, K. W., Albert, D. M., & Polans, A. S. (2011). Resveratrol metabolites do not elicit early pro-apoptotic mechanisms in neuroblastoma cells. Journal of agricultural and food chemistry, 59(9), 4979–4986. https://doi.org/10.1021/jf104901g
  59. Piliszek, A., Kwon, G. S., & Hadjantonakis, A. K. (2011). Ex utero culture and live imaging of mouse embryos. Methods in molecular biology (Clifton, N.J.), 770, 243–257. https://doi.org/10.1007/978-1-61779-210-6_9
  60. Stammet, M., Kwon, G. S., & Rao, D. A. (2010). Drug loading in Pluronic® micelles made by solvent casting and equilibrium methods using resveratrol as a model drug. Journal of controlled release : official journal of the Controlled Release Society, 148(1), e50–e51. https://doi.org/10.1016/j.jconrel.2010.07.056
  61. Bae, Y., Alani, A. W., Rockich, N. C., Lai, T. S., & Kwon, G. S. (2010). Mixed pH-sensitive polymeric micelles for combination drug delivery. Pharmaceutical research, 27(11), 2421–2432. https://doi.org/10.1007/s11095-010-0234-3
  62. Lai, T. C., Bae, Y., Yoshida, T., Kataoka, K., & Kwon, G. S. (2010). pH-sensitive multi-PEGylated block copolymer as a bioresponsive pDNA delivery vector. Pharmaceutical research, 27(11), 2260–2273. https://doi.org/10.1007/s11095-010-0092-z
  63. Bultmann, H., Girdaukas, G., Kwon, G. S., & Brandt, C. R. (2010). The virucidal EB peptide protects host cells from herpes simplex virus type 1 infection in the presence of serum albumin and aggregates proteins in a detergent-like manner. Antimicrobial agents and chemotherapy, 54(10), 4275–4289. https://doi.org/10.1128/AAC.00495-10
  64. Diezi, T. A., Bae, Y., & Kwon, G. S. (2010). Enhanced stability of PEG-block-poly(N-hexyl stearate l-aspartamide) micelles in the presence of serum proteins. Molecular pharmaceutics, 7(4), 1355–1360. https://doi.org/10.1021/mp100069p
  65. Alani, A. W., Rao, D. A., Seidel, R., Wang, J., Jiao, J., & Kwon, G. S. (2010). The effect of novel surfactants and Solutol HS 15 on paclitaxel aqueous solubility and permeability across a Caco-2 monolayer. Journal of pharmaceutical sciences, 99(8), 3473–3485. https://doi.org/10.1002/jps.22111
  66. Rao, D. A., Forrest, M. L., Alani, A. W., Kwon, G. S., & Robinson, J. R. (2010). Biodegradable PLGA based nanoparticles for sustained regional lymphatic drug delivery. Journal of pharmaceutical sciences, 99(4), 2018–2031. https://doi.org/10.1002/jps.21970
  67. Alani, A. W., Bae, Y., Rao, D. A., & Kwon, G. S. (2010). Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel. Biomaterials, 31(7), 1765–1772. https://doi.org/10.1016/j.biomaterials.2009.11.038
  68. Shin, H. C., Alani, A. W., Rao, D. A., Rockich, N. C., & Kwon, G. S. (2009). Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs. Journal of controlled release : official journal of the Controlled Release Society, 140(3), 294–300. https://doi.org/10.1016/j.jconrel.2009.04.024
  69. Pócsi, I., Leiter, E., Kwon, N. J., Shin, K. S., Kwon, G. S., Pusztahelyi, T., Emri, T., Abuknesha, R. A., Price, R. G., & Yu, J. H. (2009). Asexual sporulation signalling regulates autolysis of Aspergillus nidulans via modulating the chitinase ChiB production. Journal of applied microbiology, 107(2), 514–523. https://doi.org/10.1111/j.1365-2672.2009.04237.x
  70. Kwon, G. S., & Hadjantonakis, A. K. (2009). Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endoderm. Genesis (New York, N.Y. : 2000), 47(7), 447–455. https://doi.org/10.1002/dvg.20522
  71. Shin, K. S., Kwon, N. J., Kim, Y. H., Park, H. S., Kwon, G. S., & Yu, J. H. (2009). Differential roles of the ChiB chitinase in autolysis and cell death of Aspergillus nidulans. Eukaryotic cell, 8(5), 738–746. https://doi.org/10.1128/EC.00368-08
  72. Xiong, M. P., Yáñez, J. A., Kwon, G. S., Davies, N. M., & Forrest, M. L. (2009). A cremophor-free formulation for tanespimycin (17-AAG) using PEO-b-PDLLA micelles: characterization and pharmacokinetics in rats. Journal of pharmaceutical sciences, 98(4), 1577–1586. https://doi.org/10.1002/jps.21509
  73. Choi, Y. S., Kim, H. B., Kwon, G. S., & Park, J. K. (2009). On-chip testing device for electrochemotherapeutic effects on human breast cells. Biomedical microdevices, 11(1), 151–159. https://doi.org/10.1007/s10544-008-9220-5
  74. Park, B. D., Kim, H. G., Jung, H. J., Choi, Y. J., Kim, S. G., Kim, S. H., Kwon, G. S., & Shin, Y. W. (2009). The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 53(1), 48–52.
  75. Kwon, G. S., Viotti, M., & Hadjantonakis, A. K. (2008). The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Developmental cell, 15(4), 509–520. https://doi.org/10.1016/j.devcel.2008.07.017
  76. Kwon G. S. (2008). Editorial for theme section on polymeric micelles for drug delivery. Pharmaceutical research, 25(9), 2053–2055. https://doi.org/10.1007/s11095-008-9644-x
  77. Vakil, R., Knilans, K., Andes, D., & Kwon, G. S. (2008). Combination antifungal therapy involving amphotericin B, rapamycin and 5-fluorocytosine using PEG-phospholipid micelles. Pharmaceutical research, 25(9), 2056–2064. https://doi.org/10.1007/s11095-008-9588-1
  78. Xiong, M. P., Yáñez, J. A., Remsberg, C. M., Ohgami, Y., Kwon, G. S., Davies, N. M., & Forrest, M. L. (2008). Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats. Journal of controlled release : official journal of the Controlled Release Society, 129(1), 33–40. https://doi.org/10.1016/j.jconrel.2008.03.015
  79. Forrest, M. L., & Kwon, G. S. (2008). Clinical developments in drug delivery nanotechnology. Advanced drug delivery reviews, 60(8), 861–862. https://doi.org/10.1016/j.addr.2008.02.013
  80. Lee, J. B., Sohn, H. Y., Shin, K. S., Kim, J. S., Jo, M. S., Jeon, C. P., Jang, J. O., Kim, J. E., & Kwon, G. S. (2008). Microbial biodegradation and toxicity of vinclozolin and its toxic metabolite 3,5-dichloroaniline. Journal of microbiology and biotechnology, 18(2), 343–349.
  81. Molavi, O., Ma, Z., Mahmud, A., Alshamsan, A., Samuel, J., Lai, R., Kwon, G. S., & Lavasanifar, A. (2008). Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors. International journal of pharmaceutics, 347(1-2), 118–127. https://doi.org/10.1016/j.ijpharm.2007.06.032
  82. Vakil, R., & Kwon, G. S. (2008). Effect of cholesterol on the release of amphotericin B from PEG-phospholipid micelles. Molecular pharmaceutics, 5(1), 98–104. https://doi.org/10.1021/mp700081v
  83. Forrest, M. L., Yáñez, J. A., Remsberg, C. M., Ohgami, Y., Kwon, G. S., & Davies, N. M. (2008). Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle nanocarriers: pharmacokinetic disposition, tolerability, and cytotoxicity. Pharmaceutical research, 25(1), 194–206. https://doi.org/10.1007/s11095-007-9451-9
  84. Yáñez, J. A., Forrest, M. L., Ohgami, Y., Kwon, G. S., & Davies, N. M. (2008). Pharmacometrics and delivery of novel nanoformulated PEG-b-poly(epsilon-caprolactone) micelles of rapamycin. Cancer chemotherapy and pharmacology, 61(1), 133–144. https://doi.org/10.1007/s00280-007-0458-z
  85. Ke, S., Wright, J. C., & Kwon, G. S. (2007). Intermolecular interaction of avidin and PEGylated biotin. Bioconjugate chemistry, 18(6), 2109–2114. https://doi.org/10.1021/bc700204k
  86. Xiong, M. P., Forrest, M. L., Ton, G., Zhao, A., Davies, N. M., & Kwon, G. S. (2007). Poly(aspartate-g-PEI800), a polyethylenimine analogue of low toxicity and high transfection efficiency for gene delivery. Biomaterials, 28(32), 4889–4900. https://doi.org/10.1016/j.biomaterials.2007.07.043
  87. Bae, Y., Diezi, T. A., Zhao, A., & Kwon, G. S. (2007). Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents. Journal of controlled release : official journal of the Controlled Release Society, 122(3), 324–330. https://doi.org/10.1016/j.jconrel.2007.05.038
  88. Ke, S., Wright, J. C., & Kwon, G. S. (2007). Avidin-biotin-PEG-CPA complexes as potential EPR-directed therapeutic protein carriers: preparation and characterization. Bioconjugate chemistry, 18(5), 1644–1650. https://doi.org/10.1021/bc700182t
  89. Xiong, M. P., Bae, Y., Fukushima, S., Forrest, M. L., Nishiyama, N., Kataoka, K., & Kwon, G. S. (2007). pH-responsive Multi-PEGylated dual cationic nanoparticles enable charge modulations for safe gene delivery. ChemMedChem, 2(9), 1321–1327. https://doi.org/10.1002/cmdc.200700093
  90. Xiong, M. P., Forrest, M. L., Karls, A. L., & Kwon, G. S. (2007). Biotin-triggered release of poly(ethylene glycol)-avidin from biotinylated polyethylenimine enhances in vitro gene expression. Bioconjugate chemistry, 18(3), 746–753. https://doi.org/10.1021/bc0602883
  91. Kwon, G. S., & Hadjantonakis, A. K. (2007). Eomes::GFP-a tool for live imaging cells of the trophoblast, primitive streak, and telencephalon in the mouse embryo. Genesis (New York, N.Y. : 2000), 45(4), 208–217. https://doi.org/10.1002/dvg.20293
  92. Wang, D., Molavi, O., Lutsiak, M. E., Elamanchili, P., Kwon, G. S., & Samuel, J. (2007). Poly(D,L-lactic-co-glycolic acid) microsphere delivery of adenovirus for vaccination. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 10(2), 217–230.
  93. Forrest, M. L., Zhao, A., Won, C. Y., Malick, A. W., & Kwon, G. S. (2006). Lipophilic prodrugs of Hsp90 inhibitor geldanamycin for nanoencapsulation in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles. Journal of controlled release : official journal of the Controlled Release Society, 116(2), 139–149. https://doi.org/10.1016/j.jconrel.2006.07.003
  94. Lee, J. B., Sohn, H. Y., Shin, K. S., Jo, M. S., Kim, J. E., Lee, S. W., Shin, J. W., Kum, E. J., & Kwon, G. S. (2006). Isolation of a soil bacterium capable of biodegradation and detoxification of endosulfan and endosulfan sulfate. Journal of agricultural and food chemistry, 54(23), 8824–8828. https://doi.org/10.1021/jf061276e
  95. Vakil, R., & Kwon, G. S. (2006). Poly(ethylene glycol)-b-poly(epsilon-caprolactone) and PEG-phospholipid form stable mixed micelles in aqueous media. Langmuir : the ACS journal of surfaces and colloids, 22(23), 9723–9729. https://doi.org/10.1021/la061408y
  96. Kwon, G. S., Fraser, S. T., Eakin, G. S., Mangano, M., Isern, J., Sahr, K. E., Hadjantonakis, A. K., & Baron, M. H. (2006). Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development. Developmental dynamics : an official publication of the American Association of Anatomists, 235(9), 2549–2558. https://doi.org/10.1002/dvdy.20843
  97. Shin, K. S., Oh, H. M., Park, Y. H., Lee, K. H., Poo, H., Kwon, G. S., & Kwon, O. Y. (2006). Cryptococcus mujuensis sp. nov. and Cryptococcus cuniculi sp. nov., basidiomycetous yeasts isolated from wild rabbit faeces. International journal of systematic and evolutionary microbiology, 56(Pt 9), 2241–2244. https://doi.org/10.1099/ijs.0.64353-0
  98. Lutsiak, M. E., Kwon, G. S., & Samuel, J. (2006). Biodegradable nanoparticle delivery of a Th2-biased peptide for induction of Th1 immune responses. The Journal of pharmacy and pharmacology, 58(6), 739–747. https://doi.org/10.1211/jpp.58.6.0004
  99. Forrest, M. L., Won, C. Y., Malick, A. W., & Kwon, G. S. (2006). In vitro release of the mTOR inhibitor rapamycin from poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles. Journal of controlled release : official journal of the Controlled Release Society, 110(2), 370–377. https://doi.org/10.1016/j.jconrel.2005.10.008
  100. Molavi, O., Shayeganpour, A., Somayaji, V., Hamdy, S., Brocks, D. R., Lavasanifar, A., Kwon, G. S., & Samuel, J. (2006). Development of a sensitive and specific liquid chromatography/mass spectrometry method for the quantification of cucurbitacin I (JSI-124) in rat plasma. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 9(2), 158–164.
  101. Croy, S. R., & Kwon, G. S. (2006). Polymeric micelles for drug delivery. Current pharmaceutical design, 12(36), 4669–4684. https://doi.org/10.2174/138161206779026245
  102. Sohn, H. Y., Kum, E. J., Kwon, G. S., Jin, I., Adams, C. A., & Kuriyama, H. (2005). GLR1 plays an essential role in the homeodynamics of glutathione and the regulation of H2S production during respiratory oscillation of Saccharomyces cerevisiae. Bioscience, biotechnology, and biochemistry, 69(12), 2450–2454. https://doi.org/10.1271/bbb.69.2450
  103. Croy, S. R., & Kwon, G. S. (2005). Polysorbate 80 and Cremophor EL micelles deaggregate and solubilize nystatin at the core-corona interface. Journal of pharmaceutical sciences, 94(11), 2345–2354. https://doi.org/10.1002/jps.20301
  104. Sohn, H. Y., Kum, E. J., Kwon, G. S., Jin, I., & Kuriyama, H. (2005). Regulation of branched-chain, and sulfur-containing amino acid metabolism by glutathione during ultradian metabolic oscillation of Saccharomyces cerevisiae. Journal of microbiology (Seoul, Korea), 43(4), 375–380.
  105. Xiong, M. P., & Kwon, G. S. (2005). PEGylation of yeast cytosine deaminase for pretargeting. Journal of pharmaceutical sciences, 94(6), 1249–1258. https://doi.org/10.1002/jps.20354
  106. Kwon, G. S., Sohn, H. Y., Shin, K. S., Kim, E., & Seo, B. I. (2005). Biodegradation of the organochlorine insecticide, endosulfan, and the toxic metabolite, endosulfan sulfate, by Klebsiella oxytoca KE-8. Applied microbiology and biotechnology, 67(6), 845–850. https://doi.org/10.1007/s00253-004-1879-9
  107. Ton, G. N., Weichert, J. P., Longino, M. A., Fine, J. P., & Kwon, G. S. (2005). Methoxypoly(ethylene glycol)-conjugated carboxypeptidase A for solid tumor targeting: part II: pharmacokinetics and biodistribution in normal and tumor-bearing rodents. Journal of controlled release : official journal of the Controlled Release Society, 104(1), 155–166. https://doi.org/10.1016/j.jconrel.2005.01.015
  108. Ton, G. N., Fine, J. P., & Kwon, G. S. (2005). Methoxypoly(ethylene glycol)-conjugated carboxypeptidase A for solid tumor targeting: part I: synthesis and characterization. Journal of controlled release : official journal of the Controlled Release Society, 104(1), 129–139. https://doi.org/10.1016/j.jconrel.2005.01.016
  109. Cho, O., Choi, K. Y., Zylstra, G. J., Kim, Y. S., Kim, S. K., Lee, J. H., Sohn, H. Y., Kwon, G. S., Kim, Y. M., & Kim, E. (2005). Catabolic role of a three-component salicylate oxygenase from Sphingomonas yanoikuyae B1 in polycyclic aromatic hydrocarbon degradation. Biochemical and biophysical research communications, 327(3), 656–662. https://doi.org/10.1016/j.bbrc.2004.12.060
  110. Kim, D., Chae, J. C., Zylstra, G. J., Sohn, H. Y., Kwon, G. S., & Kim, E. (2005). Identification of two-component regulatory genes involved in o-xylene degradation by Rhodococcus sp. strain DK17. Journal of microbiology (Seoul, Korea), 43(1), 49–53.
  111. Chong, C. S., Cao, M., Wong, W. W., Fischer, K. P., Addison, W. R., Kwon, G. S., Tyrrell, D. L., & Samuel, J. (2005). Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery. Journal of controlled release : official journal of the Controlled Release Society, 102(1), 85–99. https://doi.org/10.1016/j.jconrel.2004.09.014
  112. Vakil, R., & Kwon, G. S. (2005). PEG-phospholipid micelles for the delivery of amphotericin B. Journal of controlled release : official journal of the Controlled Release Society, 101(1-3), 386–389.
  113. Adams, M., & Kwon, G. S. (2004). Spectroscopic investigation of the aggregation state of amphotericin B during loading, freeze-drying, and reconstitution of polymeric micelles. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 7(4), 1–6.
  114. Sohn, H. Y., Son, K. H., Kwon, C. S., Kwon, G. S., & Kang, S. S. (2004). Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine : international journal of phytotherapy and phytopharmacology, 11(7-8), 666–672. https://doi.org/10.1016/j.phymed.2003.09.005
  115. Sohn, H. Y., Kwon, C. S., Kwon, G. S., Lee, J. B., & Kim, E. (2004). Induction of oxidative stress by endosulfan and protective effect of lipid-soluble antioxidants against endosulfan-induced oxidative damage. Toxicology letters, 151(2), 357–365. https://doi.org/10.1016/j.toxlet.2004.03.004
  116. Jette, K. K., Law, D., Schmitt, E. A., & Kwon, G. S. (2004). Preparation and drug loading of poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles through the evaporation of a cosolvent azeotrope. Pharmaceutical research, 21(7), 1184–1191. https://doi.org/10.1023/b:pham.0000033005.25698.9c
  117. Croy, S. R., & Kwon, G. S. (2004). The effects of Pluronic block copolymers on the aggregation state of nystatin. Journal of controlled release : official journal of the Controlled Release Society, 95(2), 161–171. https://doi.org/10.1016/j.jconrel.2003.11.003
  118. Adams, M. L., Lavasanifar, A., & Kwon, G. S. (2003). Amphiphilic block copolymers for drug delivery. Journal of pharmaceutical sciences, 92(7), 1343–1355. https://doi.org/10.1002/jps.10397
  119. Adams, M. L., Andes, D. R., & Kwon, G. S. (2003). Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules, 4(3), 750–757. https://doi.org/10.1021/bm0257614
  120. Yang, Y. S., Lee, S. H., Kim, J. D., Jung, D. M., & Kwon, G. S. (2003). Automated mirror image fixation target for fundus examination by scanning laser ophthalmoscopy. Retina (Philadelphia, Pa.), 23(2), 242–245. https://doi.org/10.1097/00006982-200304000-00019
  121. Lee, S. E., Kim, J. S., Kennedy, I. R., Park, J. W., Kwon, G. S., Koh, S. C., & Kim, J. E. (2003). Biotransformation of an organochlorine insecticide, endosulfan, by Anabaena species. Journal of agricultural and food chemistry, 51(5), 1336–1340. https://doi.org/10.1021/jf0257289
  122. Adams, M. L., & Kwon, G. S. (2003). Relative aggregation state and hemolytic activity of amphotericin B encapsulated by poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugate micelles: effects of acyl chain length. Journal of controlled release : official journal of the Controlled Release Society, 87(1-3), 23–32. https://doi.org/10.1016/s0168-3659(02)00347-4
  123. Kwak, W. J., Kwon, G. S., Jin, I., Kuriyama, H., & Sohn, H. Y. (2003). Involvement of oxidative stress in the regulation of H(2)S production during ultradian metabolic oscillation of Saccharomyces cerevisiae. FEMS microbiology letters, 219(1), 99–104. https://doi.org/10.1016/S0378-1097(02)01198-9
  124. Kwon G. S. (2003). Polymeric micelles for delivery of poorly water-soluble compounds. Critical reviews in therapeutic drug carrier systems, 20(5), 357–403. https://doi.org/10.1615/critrevtherdrugcarriersyst.v20.i5.20
  125. Kwon, G. S., Kim, J. E., Kim, T. K., Sohn, H. Y., Koh, S. C., Shin, K. S., & Kim, D. G. (2002). Klebsiella pneumoniae KE-1 degrades endosulfan without formation of the toxic metabolite, endosulfan sulfate. FEMS microbiology letters, 215(2), 255–259. https://doi.org/10.1111/j.1574-6968.2002.tb11399.x
  126. Lutsiak, M. E., Robinson, D. R., Coester, C., Kwon, G. S., & Samuel, J. (2002). Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro. Pharmaceutical research, 19(10), 1480–1487. https://doi.org/10.1023/a:1020452531828
  127. Lutsiak, M. E., Kwon, G. S., & Samuel, J. (2002). Analysis of peptide and lipopeptide content in liposomes. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 5(3), 279–284.
  128. Newman, K. D., Elamanchili, P., Kwon, G. S., & Samuel, J. (2002). Uptake of poly(D,L-lactic-co-glycolic acid) microspheres by antigen-presenting cells in vivo. Journal of biomedical materials research, 60(3), 480–486. https://doi.org/10.1002/jbm.10019
  129. Lavasanifar, A., Samuel, J., Sattari, S., & Kwon, G. S. (2002). Block copolymer micelles for the encapsulation and delivery of amphotericin B. Pharmaceutical research, 19(4), 418–422. https://doi.org/10.1023/a:1015127225021
  130. Lavasanifar, A., Samuel, J., & Kwon, G. S. (2002). Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery. Advanced drug delivery reviews, 54(2), 169–190. https://doi.org/10.1016/s0169-409x(02)00015-7
  131. Lavasanifar, A., Samuel, J., & Kwon, G. S. (2002). The effect of fatty acid substitution on the in vitro release of amphotericin B from micelles composed of poly(ethylene oxide)-block-poly(N-hexyl stearate-L-aspartamide). Journal of controlled release : official journal of the Controlled Release Society, 79(1-3), 165–172. https://doi.org/10.1016/s0168-3659(01)00537-5
  132. Adams, M. L., & Kwon, G. S. (2002). The effects of acyl chain length on the micelle properties of poly(ethylene oxide)-block-poly(N-hexyl-L-aspartamide)-acyl conjugates. Journal of biomaterials science. Polymer edition, 13(9), 991–1006. https://doi.org/10.1163/156856202760319144
  133. Lavasanifar, A., Samuel, J., & Kwon, G. S. (2001). Micelles self-assembled from poly(ethylene oxide)-block-poly(N-hexyl stearate L-aspartamide) by a solvent evaporation method: effect on the solubilization and haemolytic activity of amphotericin B. Journal of controlled release : official journal of the Controlled Release Society, 77(1-2), 155–160. https://doi.org/10.1016/s0168-3659(01)00477-1
  134. Lavasanifar, A., Samuel, J., & Kwon, G. S. (2001). The effect of alkyl core structure on micellar properties of poly(ethylene oxide)-block-poly(L-aspartamide) derivatives. Colloids and surfaces. B, Biointerfaces, 22(2), 115–126. https://doi.org/10.1016/s0927-7765(01)00147-3
  135. Lavasanifar, A., Samuel, J., & Kwon, G. S. (2000). Micelles of poly(ethylene oxide)-block-poly(N-alkyl stearate L-aspartamide): synthetic analogues of lipoproteins for drug delivery. Journal of biomedical materials research, 52(4), 831–835. <a href=”https://doi.org/10.1002/1097-4636(20001215)52:43.0.co;2-k” target=”_blank” class=”publication-link”>https://doi.org/10.1002/1097-4636(20001215)52:43.0.co;2-k
  136. Aramwit, P., Yu, B. G., Lavasanifar, A., Samuel, J., & Kwon, G. S. (2000). The effect of serum albumin on the aggregation state and toxicity of amphotericin B. Journal of pharmaceutical sciences, 89(12), 1589–1593. <a href=”https://doi.org/10.1002/1520-6017(200012)89:123.0.co;2-6″ target=”_blank” class=”publication-link”>https://doi.org/10.1002/1520-6017(200012)89:123.0.co;2-6
  137. Newman, K. D., Kwon, G. S., Miller, G. G., Chlumecky, V., & Samuel, J. (2000). Cytoplasmic delivery of a macromolecular fluorescent probe by poly(d, l-lactic-co-glycolic acid) microspheres. Journal of biomedical materials research, 50(4), 591–597. <a href=”https://doi.org/10.1002/(sici)1097-4636(20000615)50:43.0.co;2-9″ target=”_blank” class=”publication-link”>https://doi.org/10.1002/(sici)1097-4636(20000615)50:43.0.co;2-9
  138. Li, Y., & Kwon, G. S. (2000). Methotrexate esters of poly(ethylene oxide)-block-poly(2-hydroxyethyl-L-aspartamide). Part I: Effects of the level of methotrexate conjugation on the stability of micelles and on drug release. Pharmaceutical research, 17(5), 607–611. https://doi.org/10.1023/a:1007529218802
  139. Kataoka, K., Matsumoto, T., Yokoyama, M., Okano, T., Sakurai, Y., Fukushima, S., Okamoto, K., & Kwon, G. S. (2000). Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. Journal of controlled release : official journal of the Controlled Release Society, 64(1-3), 143–153. https://doi.org/10.1016/s0168-3659(99)00133-9
  140. Kwon, G. S., & Okano, T. (1999). Soluble self-assembled block copolymers for drug delivery. Pharmaceutical research, 16(5), 597–600. https://doi.org/10.1023/a:1011991617857
  141. Wang, D., Robinson, D. R., Kwon, G. S., & Samuel, J. (1999). Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. Journal of controlled release : official journal of the Controlled Release Society, 57(1), 9–18. https://doi.org/10.1016/s0168-3659(98)00099-6
  142. Lee, D. S., Lee, S. H., Kwon, G. S., Lee, H. K., Woo, J. H., Kim, J. G., & Hong, S. D. (1999). Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge. Bioscience, biotechnology, and biochemistry, 63(8), 1370–1373. https://doi.org/10.1271/bbb.63.1370
  143. Yu, B. G., Okano, T., Kataoka, K., Sardari, S., & Kwon, G. S. (1998). In vitro dissociation of antifungal efficacy and toxicity for amphotericin B-loaded poly(ethylene oxide)-block-poly(beta benzyl L aspartate) micelles. Journal of controlled release : official journal of the Controlled Release Society, 56(1-3), 285–291. https://doi.org/10.1016/s0168-3659(98)00095-9
  144. Lutsiak, C. M., Sosnowski, D. L., Wishart, D. S., Kwon, G. S., & Samuel, J. (1998). Use of a liposome antigen delivery system to alter immune responses in vivo. Journal of pharmaceutical sciences, 87(11), 1428–1432. https://doi.org/10.1021/js980075p
  145. Newman, K. D., Sosnowski, D. L., Kwon, G. S., & Samuel, J. (1998). Delivery of MUC1 mucin peptide by Poly(d,l-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses. Journal of pharmaceutical sciences, 87(11), 1421–1427. https://doi.org/10.1021/js980070s
  146. Ma, J., Luo, D., Kwon, G. S., Samuel, J., Noujaim, A. A., & Madiyalakan, R. (1998). Use of encapsulated single chain antibodies for induction of anti-idiotypic humoral and cellular immune responses. Journal of pharmaceutical sciences, 87(11), 1375–1378. https://doi.org/10.1021/js9800681
  147. Ma, J., Samuel, J., Kwon, G. S., Noujaim, A. A., & Madiyalakan, R. (1998). Induction of anti-idiotypic humoral and cellular immune responses by a murine monoclonal antibody recognizing the ovarian carcinoma antigen CA125 encapsulated in biodegradable microspheres. Cancer immunology, immunotherapy : CII, 47(1), 13–20. https://doi.org/10.1007/s002620050499
  148. Kwon G. S. (1998). Diblock copolymer nanoparticles for drug delivery. Critical reviews in therapeutic drug carrier systems, 15(5), 481–512.
  149. Nam, J. S., Kwon, G. S., Lee, S. O., Hwang, J. S., Lee, J. D., Yoon, B. D., & Lee, T. H. (1996). Bioflocculant produced by Aspergillus sp. JS-42. Bioscience, biotechnology, and biochemistry, 60(2), 235–237.
  150. Kwon, G. S., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1995). Physical entrapment of adriamycin in AB block copolymer micelles. Pharmaceutical research, 12(2), 192–195. https://doi.org/10.1023/a:1016266523505
  151. Kwon, G. S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1993). Biodistribution of micelle-forming polymer-drug conjugates. Pharmaceutical research, 10(7), 970–974. https://doi.org/10.1023/a:1018998203127
  152. Yokoyama, M., Kwon, G. S., Okano, T., Sakurai, Y., Seto, T., & Kataoka, K. (1992). Preparation of micelle-forming polymer-drug conjugates. Bioconjugate chemistry, 3(4), 295–301. https://doi.org/10.1021/bc00016a007