Bugni Research Group

Publications

  1. Yan, J. X., Wu, Q., Maity, M., Braun, D. R., Alas, I., Wang, X., Yin, X., Zhu, Y., Bell, B. A., Ge, S. R., Richardson, D. D., Zhong, W., & Bugni, T. S. (2023). Rapid unambiguous structure elucidation of streptnatamide A, a new cyclic peptide isolated from a marine-derived Streptomyces sp. Chemistry, 29, e202301813.
  2. Wu, Q., Bell, B. A., Yan, J. X., Chevrette, M. G., Brittin, N. J., Zhu, Y., Chanana, S., Maity, M., Braun, D. R., Wheaton, A. M., Guzei, I. A., Ge, Y., Rajski, S. R., Thomas, M. G., & Bugni, T. S. (2023). Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora.. Journal of the American Chemical Society, 145(1), 58-69. https://doi.org/10.1021/jacs.2c06410
  3. Gotting, K., May, D. S., Sosa-Calvo, J., Khadempour, L., Francoeur, C. B., Berasategui, A., Thairu, M. W., Sandstrom, S., Carlson, C. M., Chevrette, M. G., Pupo, M. T., Bugni, T. S., Schultz, T. R., Johnston, J. S., Gerardo, N. M., & Currie, C. R. (2022). Genomic diversification of the specialized parasite of the fungus-growing ant symbiosis.. Proceedings of the National Academy of Sciences of the United States of America, 119(51), e2213096119. https://doi.org/10.1073/pnas.2213096119
  4. Zhang, F., Ramos Alvarenga, R. F., Throckmorton, K., Chanana, S., Braun, D. R., Fossen, J., Zhao, M., McCrone, S., Harper, M. K., Rajski, S. R., Rose, W. E., Andes, D. R., Thomas, M. G., & Bugni, T. S. (2022). Genome Mining and Metabolomics Unveil Pseudonochelin: A Siderophore Containing 5-Aminosalicylate from a Marine-Derived Pseudonocardia sp. Bacterium.. Organic letters, 24(22), 3998-4002. https://doi.org/10.1021/acs.orglett.2c01408
  5. u00d6zu00e7am, M., Oh, J. H., Tocmo, R., Acharya, D., Zhang, S., Astmann, T. J., Heggen, M., Ruiz-Ramu00edrez, S., Li , F., Cheng, C. C., Vivas, E., Rey, F. E., Claesen, J., Bugni, T. S., Walter, J., & van Pijkeren, J. P. (2022). A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation.. Cell host & microbe, 30(6), 824-835.e6. https://doi.org/10.1016/j.chom.2022.03.033
  6. Yan, J. X., Wu, Q., Helfrich EJN, Chevrette, M. G., Braun, D. R., Heyman, H., Ananiev, G. E., Rajski, S. R., Currie, C. R., Clardy, J., & Bugni, T. S. (2022). Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus. Marine drugs, 20(1). https://doi.org/10.3390/md20010043
  7. Hunt JFV, Li , M., Risgaard, R., Ananiev, G. E., Wildman, S., Zhang, F., Bugni, T. S., Zhao, X., & Bhattacharyya, A. (2021). High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells.. Cells, 11(1). https://doi.org/10.3390/cells11010069
  8. Scribano, C. M., Wan, J., Esbona, K., Tucker, J. B., Lasek, A., Zhou, A. S., Zasadil, L. M., Molini, R., Fitzgerald, J., Lager, A. M., Laffin, J. J., Correia-Staudt, K., Wisinski, K. B., Tevaarwerk, A. J., O’Regan, R., McGregor, S. M., Fowler, A. M., Chappell, R. J., Bugni, T. S., … Weaver, B. A. (2021). Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel.. Science translational medicine, 13(610), eabd4811. https://doi.org/10.1126/scitranslmed.abd4811
  9. Abdul-Rahim, O., Wu, Q., Price, T. K., Pistone, G., Diebel, K., Bugni, T. S., & Wolfe, A. J. (2021). Phenyl-Lactic Acid Is an Active Ingredient in Bactericidal Supernatants of Lactobacillus crispatus.. Journal of bacteriology, 203(19), e0036021. https://doi.org/10.1128/JB.00360-21
  10. Hou, L., Li , Y., Wu, Q., Li , M., Older, E. A., Tang, X., Nagarkatti, P., Nagarkatti, M., Liu, Y., Li , L., Fan, D., Bugni, T. S., Shang, Z., & Li , J. (2021). Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type III polyketide synthase.. Bioorganic chemistry, 112, 104925. https://doi.org/10.1016/j.bioorg.2021.104925
  11. Francoeur, C. B., May, D. S., Thairu, M. W., Hoang, D. Q., Panthofer, O., Bugni, T. S., Pupo, M. T., Clardy, J., Pinto-Tomu00e1s, A. A., & Currie, C. R. (2021). Burkholderia from Fungus Gardens of Fungus-Growing Ants Produces Antifungals That Inhibit the Specialized Parasite Escovopsis. Applied and environmental microbiology, 87(14), e0017821. https://doi.org/10.1128/AEM.00178-21
  12. Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., … van der Hooft JJJ (2021). A community resource for paired genomic and metabolomic data mining.. Nature chemical biology, 17(4), 363-368. https://doi.org/10.1038/s41589-020-00724-z
  13. Zhao, M., Zhang, F., Zarnowski, R., Barns, K., Jones, R., Fossen, J., Sanchez, H., Rajski, S. R., Audhya, A., Bugni, T. S., & Andes, D. R. (2021). Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking.. The Journal of clinical investigation, 131(5). https://doi.org/10.1172/JCI145123
  14. Ortega, H. E., Lourenzon, V. B., Chevrette, M. G., Ferreira LLG, Alvarenga RFR, Melo WGP, Venu00e2ncio, T., Currie, C. R., Andricopulo, A. D., Bugni, T. S., & Pupo, M. T. (2021). Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311.. Bioorganic & medicinal chemistry, 32, 116016. https://doi.org/10.1016/j.bmc.2021.116016
  15. Wu, Q., Throckmorton, K., Maity, M., Chevrette, M. G., Braun, D. R., Rajski, S. R., Currie, C. R., Thomas, M. G., & Bugni, T. S. (2021). Bacillibactins E and F from a Marine Sponge-Associated Bacillus sp.. Journal of natural products, 84(1), 136-141. https://doi.org/10.1021/acs.jnatprod.0c01170
  16. Vinnik, V., Zhang, F., Park, H., Cook, T. B., Throckmorton, K., Pfleger, B. F., Bugni, T. S., & Thomas, M. G. (2021). Structural and Biosynthetic Analysis of the Fabrubactins, Unusual Siderophores from Agrobacterium fabrum Strain C58.. ACS chemical biology, 16(1), 125-135. https://doi.org/10.1021/acschembio.0c00809
  17. Zhang, F., Zhao, M., Barns, K. J., Braun, D. R., Ericksen, S. S., Piotrowski, J. S., Nelson, J., Peng, J., Ananiev, G. E., Chanana, S., Barns, K., Fossen, J., Sanchez, H., Chevrette, M. G., Guzei, I. A., Zhao, C., Guo, C., Tang, W., Currie, C. R., … Bugni, T. S. (2020). A marine microbiome antifungal targets urgent-threat drug-resistant fungi.. Science, 370, 974-978. https://doi.org/PMC7756952
  18. Chanana, S., Braun, D. R., Rajski, S. R., & Bugni, T. S. (2020). Draft genome sequence of Pseudenhygromyxa sp. strain WMMC2535, a marine ascidian-associated bacterium. Microbiol. Resourc. Announc., 9, e00657-20. https://doi.org/PMC32816974
  19. Chanana, S., Thomas, C. S., Zhang, F., Braun, D. R., Rajski, S., & Bugni, T. S. (2020). HCA/PCA pipeline in R for untargeted metabolomics. Metabolites, 10, E297. https://doi.org/PMC7407629
  20. Zhang, F., Wyche, T. P., Zhu, Y., Braun, D. R., Yan, D. R., Chanana, S., Ge, Y., Guzei, I. A., Chevrette, M. G., Currie, C. R., Thomas, M. G., Rajski, S. R., & Bugni, T. S. (2020). MS-derived isotopic find structure reveals forazoline A as a thioketone-containing marine-derived natural product.. Org. Lett, 22, 1275-1279.
  21. Thomas, C. S., Braun, D. R., Omos, J. L., Rajski, S. R., Phillips, G. N., Andes, D., & Bugni, T. S. (2020). Pyridine 2,6 dithiocarboxylic acid and metal complexes: New inhibitors of New Delhi metallo-beta-lactamse 1.. Marine Drugs, 18, 295. https://doi.org/PMC7374359
  22. Zhao, M., Zhang, F., Zarnowski, R., Barns, K. J., Jones, R., Fossen, J. L., Sanchez, H., Rajski, S. R., Audhya, A., Bugni, T. S., & Andes, D. R. (2020). Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking.. J. Clin. Invest..
  23. Zhang, F., Zhao, M., Braun, D. R., Ericksen, S. S., Piotrowski, J. S., Nelson, J., Peng, J., Ananiev, G., Chanana, E., Barns, K., Fossen, K., Sanchez, H., Chevrette, M. G., Guzei, I. A., Zhao, C., Guo, L., Tang, W., Currie, C. R., Rajski, S. R., … Bugni, T. S. (2020). A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science, 370(6519), 974-978. https://doi.org/10.1126/science.abd6919
  24. Ortega, H. E., Ferreira, L. L., Melo, W. G., Oliveira, A. L., Alvarenga, R. R., Lopes, N. P., Bugni, T. S., Andricopulo, A. D., & Pupo, M. T. (2019). Antifungal compounds from Steptomyces associated with attine ants also inhibit Leishmania donovani. Plos Neglected Diseases, 13, e0007643.
  25. Jayanetti, D. R., Braun, D. R., Barns, K. J., & Bugni, T. S. (2019). Bulbiferates A and B: Antibacterial acetamidohydroxybenzoates from a marine Micrbulbifer sp. J. Nat. Prod, 82, 1930-1934.
  26. Zhang, F., Braun, D. R., Rajski, S. R., DeMaria, D., & Bugni, T. S. (2019). Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacterium. Enhygromyxa sp. Mar. Drugs, 17.
  27. Chevrette, M. G., Carlson, C. M., Ortega, H. E., Thomas, C., Anaiev, G. E., Barns, K. J., Cagnazzo, J., Carlos, C., Flanigan, W., Grubbs, K. J., Horn, H. A., Hoffman, F. M., Klassen, J. L., Knack, J. J., Lewin, G. R., McDonald, B. R., Muller, L., Melo, W. G., Pinto-Tomas, A. A., … Currie, C. R. (2019). New antibiotics from insect microbiomes. Nature Communications, 10, 516.
  28. Acharya, D. D., Miller, I. J., Cui, Y., Braun, D. R., Berres, M., Styles, M. J., Li, L., Kwan, J., Rajski, S. R., Blackwell, & Bugni, T. S. (2019). Omics technologies to understand activation of a biosynthetic gene cluster in Micromonospora sp. WMMB235: Deciphering keyicin biosynthesis. ACS Chem. Biol, 14, 1260-1270.
  29. Mevers, E., Sauri, J., Helfrich, E., Henke, M., Barns, K. J., Bugni, T. S., Andes, D. R., Currie, C. R., & Clardy, J. (2019). Pyonitrins A-D: Chimeric antifungal agents produced by Pseudomonas protegens. J. Am. Chem. Soc, 141, 17098-17101.
  30. Acharya, D., Miller, I., Cui, Y., Braun, D. R., Berres, M. E., Styles, M. J., Li , L., Kwan, J., Rajski, S. R., Blackwell, H. E., & Bugni, T. S. (2019). Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis.. ACS chemical biology, 14(6), 1260-1270. https://doi.org/10.1021/acschembio.9b00223
  31. Bugni, T. S., Smith, T. E., Pond, C. D., Pierce, E., Harmer, Z., Kwan, J., Zachariah, M., Harper, M. K., Wyche, T. P., Matainaho, T. K., Barrows, L. R., Ireland, C. M., & Schmidt, E. W. (2018). Assessing chemical diversity from the uncultivated symbionts of small marine animals. Nature Chemical Biology, 14, 179-185.
  32. Bugni, T. S., Zhang, F., Braun, D. R., Ananieve, G. E., Hoffman, F. M., Tsai, I. W., & Rajski, S. R. (2018). Biemamides A-E, inhibitors of the TGF-beta pathway that block the epithelial to mesenchymal transition. Organic Letters, 20, 5529-5532.
  33. Bugni, T. S., Braun, D. R., Chevrette, M. G., Acharya, D., Currie, C. R., Rajsju, S. R., & Ritchie, K. B. (2018). Complete genome sequence of Dietzia sp. strain WMMA184, a marine coral-associated bacterium. Genome Announcements, 6.
  34. Bugni, T. S., Braun, D. R., Chevrette, M. G., Acharya, D., Currie, C. R., & Rajski, S. R. (2018). Draft genome sequence of Micromonospora sp. strain WMMA1996, a marine sponge-associated bacterium. Genome Announcements, 6.
  35. Wyche, T., Alvarenga, R., Piotrowski, J., Duster, M., Warrack, S., Cornilescu, G., Hou, Y., De Wolfe, T., Braun, D., Ellis, G., Simpkins, S., Nelson, J., Myers, C., Steele, J., Mori, H., Safdar, N., Markley, J., Rajski, J., & Bugni, T. S. (2017). Chemical genomics, structure elucidation, and in vivo studies of the marine-derived anticlostridial ecteinamycin. ACS Chem. Bio, 12, 2287-2295.
  36. Wyche, T. P., Alvarenga, R. F., Piotrowski, J. S., Duster, M. N., Warrack, S., Cornilescu, G., De Wolfe, T. J., Hou, Y., Braun, D., Ellis, G. A., Simpkins, S. W., Nelson, J., Meyers, C. L., Steele, J. L., Mori, H., Safdar, N., Markley, J. L., Rajski, S. R., & Bugni, T. S. (2017). Chemical genomics, structure elucidation, and in vivo studies of the marine-derived anticlostridial ecteinamycin. ACS Chemical Biology(12), 2287-2295.
  37. Adnani, N., Chevrette, M. G., Adibhatla, S. N., Zhang, F., Yu, Q., Braun, D. R., Nelson, J., Simpkins, S. W., McDonald, B. R., Meyers, C. L., Piotrowski, J., Thompson, C. J., Currie, C. R., Li, L., Rajski, S. R., & Bugni, T. S. (2017). Co-culture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic keyicin. ACS Chemical Biology(12), 3093-3102.
  38. Cornilescu, G., Alvarenga, R., Wyche, T., Bugni, T. S., Gil, R., Cornilescu, C., Westler, W., Markley, J., & Schweiters, C. (2017). NIH, National Center for Accelerating Translational Sciences. ACS Chem. Bio, 12, 2157-2163.
  39. Chanana, S., Thomas, C. S., Braun, D. R., Hou, Y., Wyche, T. P., & Bugni, T. S. (2017). PoPCAR: Planes of Principal Component Analysis in R. Metabolites.
  40. Cornilescu, G., Alvarenga, R. F., Wyche, T. P., Bugni, T. S., Gil, R. R., Cornilescu, C. C., Westler, W. M., Markley, J. L., & Schweiters, C. D. (2017). Progressive stereo-locking (PSL) – A residual dipolar coupling based force field method for determining the relative configuration of natural products and other small molecules. ACS Chemical Biology(12), 2157-2163.
  41. Adnani, N., Rajski, S., & Bugni, T. S. (2017). Symbiosis-inspired approaches to antibiotic discovery. Natural Product Reports(34), 784-814.
  42. Zhang, F., Barns, K., Hoffmann, F., Braun, D. R., Andes, D. R., & Bugni, T. S. (2017). Thalassosamide, a Siderophore, Discovered from a Marine-derived Bacterium Thalassospira profundimaris. J. Nat. Prod.(80), 2551-2555.
  43. Ellis, G. A., Thomas, C. S., Chanana, S., Adnani, N., Szachowicz, E., Braun, D. R., Harper, M. K., Wyche, T. P., & Bugni, T. S. (2017). Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges. PLoS One(12).
  44. Adnani, N., Rajski, S. R., & Bugni, T. S. (2017). Symbiosis-inspired approaches to antibiotic discovery.. Natural product reports. https://doi.org/10.1039/c7np00009j
  45. Beemelmanns, C., Ramadhar, T. R., Kim, K. H., Klassen, J. L., Cao, S., Wyche, T. P., Hou, Y., Poulsen, M., Bugni, T. S., Currie, C. R., & Clardy, J. (2017). Macrotermycins A-D, Glycosylated Macrolactams from a Termite-Associated Amycolatopsis sp. M39.. Organic letters, 19(5), 1000-1003. https://doi.org/10.1021/acs.orglett.6b03831
  46. Bugni, T. S. (2017). Review of Mass Spectrometry: Instrumentation, Interpretation, and Applications Mass Spectrometry: Instrumentation, Interpretation, and Applications . Edited by Rolf Ekman, Jerzy Silberring, Ann M. Westman-Brinkmalm, and Agnieszka Kraj. Wiley , New York , 2009 . 388 pp. $149.00. ISBN 978-0-471-71395-1 .. Journal of natural products, 80(2), 574-575. https://doi.org/10.1021/acs.jnatprod.7b00030
  47. Adnani, N., Braun, D. R., McDonald, B. R., Chevrette, M. G., Currie, C. R., & Bugni, T. S. (2017). Draft Genome Sequence of Micromonospora sp. Strain WMMB235, a Marine Ascidian-Associated Bacterium.. Genome announcements, 5(2). https://doi.org/10.1128/genomeA.01369-16
  48. Wyche, T. P., Ruzzini, A. C., Beemelmanns, C., Kim, K. H., Klassen, J. L., Cao, S., Poulsen, M., Bugni, T. S., Currie, C. R., & Clardy, J. (2017). Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides.. Organic letters, 19(7), 1772-1775. https://doi.org/10.1021/acs.orglett.7b00545
  49. Adnani, N., Braun, D. R., McDonald, B. R., Chevrette, M. G., Currie, C. R., & Bugni, T. S. (2016). Complete Genome Sequence of Rhodococcus sp. Strain WMMA185, a Marine Sponge-Associated Bacterium.. Genome announcements, 4(6). https://doi.org/10.1128/genomeA.01406-16
  50. Zhang, Y., Adnani, N., Braun, D. R., Ellis, G. A., Barns, K. J., Parker-Nance, S., Guzei, I. A., & Bugni, T. S. (2016). Micromonohalimanes A and B: Antibacterial Halimane-Type Diterpenoids from a Marine Micromonospora Species.. Journal of natural products, 79(11), 2968-2972. https://doi.org/10.1021/acs.jnatprod.6b00555
  51. Reibarkh, M., Wyche, T. P., Sauru00ed, J., Bugni, T. S., Martin, G. E., & Thomas Williamson, R. (2015). Structure elucidation of uniformly (13)C labeled small molecule natural products.. Magnetic resonance in chemistry : MRC, 53(12), 996-1002. https://doi.org/10.1002/mrc.4333
  52. Adnani, N., Vazquez-Rivera, E., Adibhatla, S. N., Ellis, G. A., Braun, D. R., & Bugni, T. S. (2015). Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach.. Marine drugs, 13(10), 6082-98. https://doi.org/10.3390/md13106082
  53. Zhang, F., Adnani, N., Vazquez-Rivera, E., Braun, D. R., Tonelli, M., Andes, D. R., & Bugni, T. S. (2015). Application of 3D NMR for Structure Determination of Peptide Natural Products.. The Journal of organic chemistry, 80(17), 8713-9. https://doi.org/10.1021/acs.joc.5b01486
  54. Tianero, M. D., Kwan, J., Wyche, T. P., Presson, A. P., Koch, M., Barrows, L. R., Bugni, T. S., & Schmidt, E. W. (2015). Species specificity of symbiosis and secondary metabolism in ascidians.. The ISME journal, 9(3), 615-28. https://doi.org/10.1038/ismej.2014.152
  55. Adnani, N., Ellis, G. A., Wyche, T. P., Bugni, T. S., Kwan, J., & Schmidt, E. W. (2014). Emerging trends for stimulating the discovery of natural products. Natural Products Analysis – Instrumentation, Methods, and Applications. Wiley.
  56. Wyche, T. P., Dammalapati, A., Cho, H., Harrison, A. D., Kwon, G. S., Chen, H., Bugni, T. S., & Jaskula-Sztul, R. (2014). Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo.. Cancer gene therapy, 21(12), 518-25. https://doi.org/10.1038/cgt.2014.57
  57. Wyche, T. P., Piotrowski, J. S., Hou, Y., Braun, D., Deshpande, R., McIlwain, S., Ong, I. M., Myers, C. L., Guzei, I. A., Westler, W. M., Andes, D. R., & Bugni, T. S. (2014). Forazolineu2005A: marine-derived polyketide with antifungal inu2005vivo efficacy.. Angewandte Chemie (International ed. in English), 53(43), 11583-6. https://doi.org/10.1002/anie.201405990
  58. Ellis, G. A., Wyche, T. P., Fry, C. G., Braun, D. R., & Bugni, T. S. (2014). Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp.. Marine drugs, 12(2), 1013-22. https://doi.org/10.3390/md12021013
  59. Wyche, T. P., Standiford, M., Hou, Y., Braun, D., Johnson, D. A., Johnson, J. A., & Bugni, T. S. (2013). Activation of the nuclear factor E2-related factor 2 pathway by novel natural products halomadurones A-D and a synthetic analogue.. Marine drugs, 11(12), 5089-99. https://doi.org/10.3390/md11125089
  60. Li , Q., Xu, Y. S., Ellis, G. A., Bugni, T. S., Tang, Y., & Hsung, R. P. (2013). Total Syntheses of Proposed (u00b1)-Trichodermatides B and C.. Tetrahedron letters, 54(41). https://doi.org/10.1016/j.tetlet.2013.07.137
  61. Tesfazghi, S., Eide, J., Dammalapati, A., Korlesky, C., Wyche, T. P., Bugni, T. S., Chen, H., & Jaskula-Sztul, R. (2013). Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line.. Cancer medicine, 2(5), 734-43. https://doi.org/10.1002/cam4.118
  62. Reilly, C. A., Henion, F., Bugni, T. S., Ethirajan, M., Stockmann, C., Pramanik, K. C., Srivastava, S. K., & Yost, G. S. (2013). Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.. Chemical research in toxicology, 26(1), 55-66. https://doi.org/10.1021/tx300366k
  63. Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., Cotter, P. D., Craik, D. J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P. C., Entian, K. D., Fischbach, M. A., Garavelli, J. S., … van der Donk, W. A. (2013). Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.. Natural product reports, 30(1), 108-60. https://doi.org/10.1039/c2np20085f
  64. Tibrewal, N., Pahari, P., Wang, G., Kharel, M. K., Morris, C., Downey, T., Hou, Y., Bugni, T. S., & Rohr, J. (2012). Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis.. Journal of the American Chemical Society, 134(44), 18181-4. https://doi.org/10.1021/ja3081154
  65. Zhou, M., Hou, Y., Hamza, A., Pain, C., Zhan, C. G., Bugni, T. S., & Thorson, J. S. (2012). Probing the regiospecificity of enzyme-catalyzed steroid glycosylation.. Organic letters, 14(21), 5424-7. https://doi.org/10.1021/ol3024924
  66. Hou, Y., Tianero, M. D., Kwan, J., Wyche, T. P., Michel, C. R., Ellis, G. A., Vazquez-Rivera, E., Braun, D. R., Rose, W. E., Schmidt, E. W., & Bugni, T. S. (2012). Structure and biosynthesis of the antibiotic bottromycin D.. Organic letters, 14(19), 5050-3. https://doi.org/10.1021/ol3022758
  67. Liu, R., Zhang, M., Wyche, T. P., Winston-McPherson, G. N., Bugni, T. S., & Tang, W. (2012). Stereoselective preparation of cyclobutanes with four different substituents: total synthesis and structural revision of pipercyclobutanamide A and piperchabamide G.. Angewandte Chemie (International ed. in English), 51(30), 7503-6. https://doi.org/10.1002/anie.201203379
  68. Lim, F. Y., Hou, Y., Chen, Y., Oh, J. H., Lee, I., Bugni, T. S., & Keller, N. P. (2012). Genome-based cluster deletion reveals an endocrocin biosynthetic pathway in Aspergillus fumigatus.. Applied and environmental microbiology, 78(12), 4117-25. https://doi.org/10.1128/AEM.07710-11
  69. Carr, G., Poulsen, M., Klassen, J. L., Hou, Y., Wyche, T. P., Bugni, T. S., Currie, C. R., & Clardy, J. (2012). Microtermolides A and B from termite-associated Streptomyces sp. and structural revision of vinylamycin.. Organic letters, 14(11), 2822-5. https://doi.org/10.1021/ol301043p
  70. Hou, Y., Braun, D. R., Michel, C. R., Klassen, J. L., Adnani, N., Wyche, T. P., & Bugni, T. S. (2012). Microbial strain prioritization using metabolomics tools for the discovery of natural products.. Analytical chemistry, 84(10), 4277-83. https://doi.org/10.1021/ac202623g
  71. Wyche, T. P., Hou, Y., Vazquez-Rivera, E., Braun, D., & Bugni, T. S. (2012). Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.. Journal of natural products, 75(4), 735-40. https://doi.org/10.1021/np300016r
  72. Adnani, N., Michel, C. R., & Bugni, T. S. (2012). Universal quantification of structurally diverse natural products using an evaporative light scattering detector.. Journal of natural products, 75(4), 802-6. https://doi.org/10.1021/np300034c
  73. Hu, K., Wyche, T. P., Bugni, T. S., & Markley, J. L. (2011). Selective quantification by 2D HSQC0 spectroscopy of thiocoraline in an extract from a sponge-derived Verrucosispora sp.. Journal of natural products, 74(10), 2295-8. https://doi.org/10.1021/np200503c
  74. Wyche, T. P., Hou, Y., Braun, D., Cohen, H. C., Xiong, M. P., & Bugni, T. S. (2011). First natural analogs of the cytotoxic thiodepsipeptide thiocoraline A from a marine Verrucosispora sp.. The Journal of organic chemistry, 76(16), 6542-7. https://doi.org/10.1021/jo200661n
  75. Pimentel-Elardo, S. M., Buback, V., Gulder, T. A., Bugni, T. S., Reppart, J., Bringmann, G., Ireland, C. M., Schirmeister, T., & Hentschel, U. (2011). New tetromycin derivatives with anti-trypanosomal and protease inhibitory activities.. Marine drugs, 9(10), 1682-97. https://doi.org/10.3390/md9101682
  76. Koch, M., Bugni, T. S., Sondossi, M., Ireland, C. M., & Barrows, L. R. (2010). Exocarpic acid inhibits mycolic acid biosynthesis in Mycobacterium tuberculosis.. Planta medica, 76(15), 1678-82. https://doi.org/10.1055/s-0030-1249939
  77. Coombs, G. S., Yu, J., Canning, C. A., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z. H., Jadulco, R. C., Concepcion, G. P., Bugni, T. S., Harper, M. K., Mihalek, I., Jones, C. M., Ireland, C. M., & Virshup, D. M. (2010). WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.. Journal of cell science, 123(Pt 19), 3357-67. https://doi.org/10.1242/jcs.072132
  78. Wei, X., Bugni, T. S., Harper, M. K., Sandoval, I. T., Manos, E. J., Swift, J., Van Wagoner, R. M., Jones, D. A., & Ireland, C. M. (2010). Evaluation of pyridoacridine alkaloids in a zebrafish phenotypic assay.. Marine drugs, 8(6), 1769-78. https://doi.org/10.3390/md8061769
  79. Luo, Y., Li , W., Ju, J., Yuan, Q., Peters, N. R., Hoffmann, F. M., Huang, S. X., Bugni, T. S., Rajski, S., Osada, H., & Shen, B. (2010). Functional characterization of TtnD and TtnF, unveiling new insights into tautomycetin biosynthesis.. Journal of the American Chemical Society, 132(19), 6663-71. https://doi.org/10.1021/ja9082446
  80. Pimentel-Elardo, S. M., Kozytska, S., Bugni, T. S., Ireland, C. M., Moll, H., & Hentschel, U. (2010). Anti-parasitic compounds from Streptomyces sp. strains isolated from Mediterranean sponges.. Marine drugs, 8(2), 373-80. https://doi.org/10.3390/md8020373
  81. Pan, J. J., Bugni, T. S., & Poulter, C. D. (2009). Recombinant squalene synthase. synthesis of cyclopentyl non-head-to-tail triterpenes.. The Journal of organic chemistry, 74(19), 7562-5. https://doi.org/10.1021/jo9014547
  82. Koch, M., Bugni, T. S., Pond, C. D., Sondossi, M., Dindi, M., Piskaut, P., Ireland, C. M., & Barrows, L. R. (2009). Antimycobacterial activity of Exocarpos latifolius is due to exocarpic acid.. Planta medica, 75(12), 1326-30. https://doi.org/10.1055/s-0029-1185687
  83. McCulloch, M. W., Bugni, T. S., Concepcion, G. P., Coombs, G. S., Harper, M. K., Kaur, S., Mangalindan, G. C., Mutizwa, M. M., Veltri, C. A., Virshup, D. M., & Ireland, C. M. (2009). Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.. Journal of natural products, 72(9), 1651-6. https://doi.org/10.1021/np900336f
  84. Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Feng, X., Jin, G., Harper, M. K., Mangalindan, G. C., McDonald, L. A., & Ireland, C. M. (2009). Fibrosterol sulfates from the Philippine sponge Lissodendoryx (Acanthodoryx) fibrosa: sterol dimers that inhibit PKCzeta.. The Journal of organic chemistry, 74(16), 5902-8. https://doi.org/10.1021/jo900844r
  85. Barrows, L. R., Matainaho, T. K., Ireland, C. M., Miller, S., Carter, G. T., Bugni, T. S., Rai, P., Gideon, O., Manoka, B., Piskaut, P., Banka, R., Kiapranis, R., Noro, J. N., Pond, C. D., Andjelic, C. D., Koch, M., Harper, M. K., Powan, E., Pole, A. R., & Jensen, J. B. (2009). Making the most of Papua New Guinea’s biodiversity: Establishment of an integrated set of programs that link botanical survey with pharmacological assessment in “The Land of the Unexpected”. Pharmaceutical biology, 47(8), 795-808. https://doi.org/10.1080/13880200902991599
  86. Bugni, T. S., Andjelic, C. D., Pole, A. R., Rai, P., Ireland, C. M., & Barrows, L. R. (2009). Biologically active components of a Papua New Guinea analgesic and anti-inflammatory lichen preparation.. Fitoterapia, 80(5), 270-3. https://doi.org/10.1016/j.fitote.2009.03.003
  87. McCulloch, M. W., Coombs, G. S., Banerjee, N., Bugni, T. S., Cannon, K. M., Harper, M. K., Veltri, C. A., Virshup, D. M., & Ireland, C. M. (2009). Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives.. Bioorganic & medicinal chemistry, 17(6), 2189-98. https://doi.org/10.1016/j.bmc.2008.10.077
  88. Whitson, E. L., Ratnayake, A. S., Bugni, T. S., Harper, M. K., & Ireland, C. M. (2009). Isolation, structure elucidation, and synthesis of eudistomides A and B, lipopeptides from a Fijian ascidian Eudistoma sp.. The Journal of organic chemistry, 74(3), 1156-62. https://doi.org/10.1021/jo8022582
  89. Noro, J. C., Barrows, L. R., Gideon, O. G., Ireland, C. M., Koch, M., Matainaho, T., Piskaut, P., Pond, C. D., & Bugni, T. S. (2008). Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis.. Journal of natural products, 71(9), 1623-4. https://doi.org/10.1021/np800082e
  90. Whitson, E. L., Bugni, T. S., Chockalingam, P. S., Concepcion, G. P., Harper, M. K., He, M., Hooper, J. N., Mangalindan, G. C., Ritacco, F., & Ireland, C. M. (2008). Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.. Journal of natural products, 71(7), 1213-7. https://doi.org/10.1021/np8001628
  91. Bugni, T. S., Harper, M. K., McCulloch, M. W., Reppart, J., & Ireland, C. M. (2008). Fractionated marine invertebrate extract libraries for drug discovery.. Molecules (Basel, Switzerland), 13(6), 1372-83.
  92. Bugni, T. S., Richards, B., Bhoite, L., Cimbora, D., Harper, M. K., & Ireland, C. M. (2008). Marine natural product libraries for high-throughput screening and rapid drug discovery.. Journal of natural products, 71(6), 1095-8. https://doi.org/10.1021/np800184g
  93. Mohammed, K. A., Jadulco, R. C., Bugni, T. S., Harper, M. K., Sturdy, M., & Ireland, C. M. (2008). Strongylophorines: natural product inhibitors of hypoxia-inducible factor-1 transcriptional pathway.. Journal of medicinal chemistry, 51(5), 1402-5. https://doi.org/10.1021/jm7010854
  94. LaBarbera, D. V., Bugni, T. S., & Ireland, C. M. (2007). The total synthesis of neoamphimedine.. The Journal of organic chemistry, 72(22), 8501-5. https://doi.org/10.1021/jo7017813
  95. Laird, D. W., LaBarbera, D. V., Feng, X., Bugni, T. S., Harper, M. K., & Ireland, C. M. (2007). Halogenated cyclic peptides isolated from the sponge Corticium sp.. Journal of natural products, 70(5), 741-6. https://doi.org/10.1021/np060489v
  96. Whitson, E. L., Mala, S. M., Veltri, C. A., Bugni, T. S., de Silva, E. D., & Ireland, C. M. (2006). Oppositines A and B, sesquiterpene pyridine alkaloids from a Sri Lankan Pleurostylia opposita.. Journal of natural products, 69(12), 1833-5. https://doi.org/10.1021/np060459s
  97. Bugni, T. S., Woolery, M., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2006). Bohemamines from a marine-derived Streptomyces sp.. Journal of natural products, 69(11), 1626-8. https://doi.org/10.1021/np0602721
  98. Ratnayake, A. S., Bugni, T. S., Feng, X., Harper, M. K., Skalicky, J. J., Mohammed, K. A., Andjelic, C. D., Barrows, L. R., & Ireland, C. M. (2006). Theopapuamide, a cyclic depsipeptide from a Papua New Guinea lithistid sponge Theonella swinhoei.. Journal of natural products, 69(11), 1582-6. https://doi.org/10.1021/np060229d
  99. Lira, S. P., Vita-Marques, A. M., Seleghim, M. H., Bugni, T. S., LaBarbera, D. V., Sette, L. D., Sponchiado, S. R., Ireland, C. M., & Berlinck, R. G. (2006). New destruxins from the marine-derived fungus Beauveria felina.. The Journal of antibiotics, 59(9), 553-63. https://doi.org/10.1038/ja.2006.76
  100. Ratnayake, A. S., Bugni, T. S., Veltri, C. A., Skalicky, J. J., & Ireland, C. M. (2006). Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues.. Organic letters, 8(10), 2171-4. https://doi.org/10.1021/ol0606583
  101. Chevallier, C., Bugni, T. S., Feng, X., Harper, M. K., Orendt, A. M., & Ireland, C. M. (2006). Tedanolide C: a potent new 18-membered-ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp.. The Journal of organic chemistry, 71(6), 2510-3. https://doi.org/10.1021/jo052285+
  102. Janso, J. E., Bernan, V. S., Greenstein, M., Bugni, T. S., & Ireland, C. M. (2005). Penicillium dravuni, a new marine-derived species from an alga in Fiji.. Mycologia, 97(2), 444-53.
  103. Bugni, T. S., Janso, J. E., Williamson, R. T., Feng, X., Bernan, V. S., Greenstein, M., Carter, G. T., Maiese, W. M., & Ireland, C. M. (2004). Dictyosphaeric acids A and B: new decalactones from an undescribed Penicillium sp. obtained from the alga Dictyosphaeria versluyii.. Journal of natural products, 67(8), 1396-9. https://doi.org/10.1021/np049973t
  104. Sandoval, I. T., Davis, R. A., Bugni, T. S., Concepcion, G. P., Harper, M. K., & Ireland, C. M. (2004). Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.. Natural product research, 18(1), 89-93. https://doi.org/10.1080/1057563031000122130
  105. Bugni, T. S., & Ireland, C. M. (2004). Marine-derived fungi: a chemically and biologically diverse group of microorganisms.. Natural product reports, 21(1), 143-63. https://doi.org/10.1039/b301926h
  106. Stierle, A. A., Stierle, D. B., Goldstein, E., Parker, K., Bugni, T. S., Baarson, C., Gress, J., & Blake, D. (2003). A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile.. Journal of natural products, 66(8), 1097-100. https://doi.org/10.1021/np030044w
  107. Stierle, D. B., Stierle, A. A., & Bugni, T. S. (2003). Sequoiamonascins a-d: novel anticancer metabolites isolated from a redwood endophyte.. The Journal of organic chemistry, 68(12), 4966-9. https://doi.org/10.1021/jo0340253
  108. Bugni, T. S., Bernan, V. S., Greenstein, M., Janso, J. E., Maiese, W. M., Mayne, C. L., & Ireland, C. M. (2003). Brocaenols A-C: novel polyketides from a marine derived Penicillium brocae.. The Journal of organic chemistry, 68(5), 2014-7. https://doi.org/10.1021/jo020597w
  109. Tasdemir, D., Bugni, T. S., Mangalindan, G. C., Concepciu00f3n, G. P., Harper, M. K., & Ireland, C. M. (2002). Cytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp.. Zeitschrift fur Naturforschung. C, Journal of biosciences, 57(9-10), 914-22.
  110. Torres, Y. R., Bugni, T. S., Berlinck, R. G., Ireland, C. M., Magalhu00e3es, A., Ferreira, A. G., & Da Moreira Rocha, R. (2002). Sebastianines A and B, novel biologically active pyridoacridine alkaloids from the Brazilian ascidian Cystodytes dellechiajei.. The Journal of organic chemistry, 67(15), 5429-32.
  111. Bugni, T. S., Concepciu00f3n, G. P., Mangalindan, G. C., Harper, M. K., James, R. D., & Ireland, C. M. (2002). p-Sulfooxyphenylpyruvic acid from the red macro alga Ceratodictyon spongiosum and its sponge symbiont Haliclona cymaeformis.. Phytochemistry, 60(4), 361-3.
  112. Stierle, A. A., Stierle, D. B., & Bugni, T. S. (2001). Sequoiatones C-f, constituents of the redwood endophyte Aspergillus parasiticus.. Journal of natural products, 64(10), 1350-3.
  113. Bugni, T. S., Abbanat, D., Bernan, V. S., Maiese, W. M., Greenstein, M., Van Wagoner, R. M., & Ireland, C. M. (2000). Yanuthones: novel metabolites from a marine isolate of Aspergillus niger.. The Journal of organic chemistry, 65(21), 7195-200.
  114. Stierle, A. A., Stierle, D. B., & Bugni, T. S. (1999). Sequoiatones A and B: Novel Antitumor Metabolites Isolated from a Redwood Endophyte.. The Journal of organic chemistry, 64(15), 5479-5484.
  115. Stierle, D. B., Stierle, A. A., Bugni, T. S., & Loewen, G. (1998). Gloeolactone, a New Epoxy Lactone from a Blue-Green Alga. Journal of natural products, 61(2), 251-2. https://doi.org/10.1021/np9703398